(R)-Gyramide A (hydrochloride)
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 uM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 uM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.